Communications

Chiral acyclic diaminocarbene complexes of palladium(II), platinum(II) and gold(I) from metal-mediated coupling of isocyanides with chiral amino acid amides

T. B. Anisimova^a, M. V. Kashina^b, M. A. Kinzhalov^b, M. С. Guedes da Silva^a, A. J. Pombeiro^a, K. V. Luzyanin<sup>c

a</sup> Centro de Química Estrutural, Instituto Supérior Técnico, Universidade de Lisboa, 1049-001 Lisbon, Portugal
^b Institute of Chemistry, St. Petersburg State University, 198504 St. Petersburg, Russian Federation
^c Department of Chemistry, University of Liverpool, L69 7ZD Liverpool, United Kingdom

Abstract: The reaction between enantiopure amino acid amides and metal-coordinated isocyanides such as cis-[Cl₂M(CNR)₂] (M = Pd, Pt) and [ClAu(CNR)] affords chiral acyclic diaminocarbene complexes in 64 to 91% yields with full retention of configuration at stereogenic centers. Structural analysis of the representative Pd^II complexes revealed isostructural enantiomeric pairs with slightly distorted square-planar geometry, featuring labile Pd–Cl bonds trans to the ADC ligand.

Keywords: aminocarbene complexes, palladium complexes, platinum complexes, gold complexes, isocyanide complexes, chiral complexes, amino acid amides.

Received: 29.07.2025
Accepted: 10.10.2025

Language: English

DOI: 10.71267/mencom.7888