Communications

Synthesis of 2-sulfamoylquinoxaline 1,4-dioxide derivatives

G. I. Buravchenko, A. E. Shchekotikhin

G. F. Gause Research Institute for the Development of New Antibiotics, 119021 Moscow, Russian Federation

Abstract: An access to new sulfonamide-containing 3-phenylquinoxaline 1,4-dioxides has been accomplished via the Beirut reaction of benzofuroxans with N-(tert-butyl)-2-oxo-2-phenylethane-1-sulfonamide. The reaction of 5-aminobenzofuroxan derivatives afforded 7-amino-2-sulfamoylquinoxaline 1,4-dioxides, whereas nucleophilic substitution of the chlorine atom in 6,7-dichloro-2-sulfamoylquinoxaline 1,4-dioxide gave the corresponding 6-amino-substituted analogs.

Keywords: 2-oxo-2-phenylethane-1-sulfonamide, quinoxaline 1,4-dioxides, sulfonamides, Beirut reaction, nucleophilic substitution.

Received: 07.07.2025
Accepted: 21.08.2025

Language: English

DOI: 10.71267/mencom.7868

Bibliographic databases:

•