Communications

Regioselective synthesis of novel derivatives of neo oxo carboxylic acids with two different functional groups from linear carboxylic acid chlorides

L. V. Afanas'eva, D. V. Avetisyan, O. I. Artyushin, E. V. Smirnova, M. V. Andreev, V. V. Burlakov

A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119334 Moscow, Russian Federation

Abstract: A selective ‘one-pot’ method has been developed for the synthesis of derivatives of neo oxo carboxylic acids with two different remote functional groups from linear acid chlorides, carbon monoxide, and two different nucleophiles. The transformation is promoted by the superelectrophilic system CBr₄·2AlBr₃. No other systems initiate such transformations.

Keywords: neo-alkanoic compounds, bifunctional compounds, oxo carboxylic acids, linear carboxylic acid chlorides, C–H functionalization, superelectrophilic complex, carbon monoxide

Received: 14.04.2025
Accepted: 02.07.2025

Language: English

DOI: 10.71267/mencom.7799

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