Communications

Synthesis of 3-amino triterpenes involving the NaBH₃CN/MoCl₅ reduction of the oxime precursors

A. A. Shalina^a, L. R. Idrisova^a, A. V. Nemtarev^ab, T. I. Abdullin^a, V. F. Mironov<sup>b

a</sup> Kazan (Volga Region) Federal University, 420008 Kazan, Russian Federation
^b A. E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, 420088 Kazan, Russian Federation

Abstract: A new efficient method for the preparation of 3-amino derivatives of pentacyclic lupane and germanicane triterpenoids, valuable precursors for the rational design of physiologically active agents, is presented. The key step involves the reduction of triterpenoid 3-oximes with sodium cyanoborohydride in the presence of molybdenum(v) chloride.

Keywords: triterpenes, betulin, allobetulin, lupane type, molybdenum(v) chloride, reduction reaction, sodium cyanoborohydride, oximes, amines.

Received: 07.02.2025
Accepted: 31.03.2025

Language: English

DOI: 10.71267/mencom.7744

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