This article is cited in 1 paper

Communications

Synthesis of 1,4,2,6-dithiadiazinane 1,1-dioxide and study of its cytotoxic activity

R. R. Khairullina, L. U. Dzhemileva, V. A. D'yakonov, A. G. Ibragimov, U. M. Dzhemilev

Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: Cyclothiomethylation of sulfamide using paraformaldehyde or bis(dimethylamino)methane, hydrogen sulfide or its sodium salts catalyzed by rare-earth salts affords 1,4,2,6-dithiadi azinane 1,1-dioxide. The heterocycle was found to exhibit a pronounced cytotoxic effect against suspension tumor cell lines (Jurkat, HL60, K562, and U937).

Keywords: Cyclothiomethylation, Sulfamide, Catalysis, Hydrogen sulfide, Sodium sulfide, Samarium compounds, Ytterbium compounds, 1,4,2,6-Dithiadiazinane 1, 1-Dioxide, Cytotoxic activity.

Language: English

DOI: 10.1016/j.mencom.2022.03.008

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