Communications

Efficient one-pot synthesis of 2-(2-hydroxyaryl)-2,4,4-trimethylchromanes from 1-(2-hydroxyaryl)ethanones

D. A. Tatarinov^ab, E. A. Mikulenkova^ab, I. A. Litvinov^a, V. F. Mironov<sup>a

a</sup> A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation
^b Alexander Butlerov Institute of Chemistry, Kazan Federal University, Kazan, Russian Federation

Abstract: A one-pot synthesis of 2-(2-hydroxyaryl)-2,4,4-trimethyl-chromanes in near quantitative yields is based on the reaction of 1-(2-hydroxyaryl)ethanones with methylmagnesium iodide followed by treatment with dilute sulfuric acid. The structure of 2-(2-hydroxyphenyl)-2,4,4-trimethylchromane is confirmed by X-ray diffraction.

Keywords: 2,4,4-trimethylchromanes, 1-(2-hydroxyaryl)ethanones, Grignard synthesis, [4 + 2]-cycloaddition, dehydration, crystal structure.

Language: English

DOI: 10.1016/j.mencom.2023.10.037

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