This article is cited in 13 papers

1,3,4-Oxa(thia)diazino [i,j]-annelated quinolines: a new type of key intermediate in the synthesis of tricyclic fluoroquinolones

G. N. Lipunova, E. V. Nosova, V. N. Charushin, L. P. Sidorova, O. M. Chasovskikh

Department of Organic Chemistry, Urals State Technical University, Ekaterinburg, Russian Federation

Abstract: The synthesis of new derivatives of 1,3,4-oxa(thia)diazino[6,5,4-i,j]quinolines, which have a structure that is very similar to the ofloxacin skeleton, by intramolecular cyclizations of ethyl 3-(R-carbonylhydrazino)- and 3-(R-thiocarbonylhydrazino)-substituted 2-polyfluorobenzoyl acrylates, is described.

Language: English

DOI: 10.1070/MC1998v008n04ABEH000986

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