M. N. Dimukhametov, E. Yu. Davydova, E. V. Bayandina, A. B. Dobrynin, I. A. Litvinov, V. A. Alfonsov, “Stereospecific intramolecular cyclization of diethyl (R)-2-(N-benzylidene)-aminobutyl phosphite into (3R,5R)-2-ethoxy-2-oxo-3-phenyl-5-ethyl-1,4,2-oxazaphosphorinane in the presence of hydrogen chloride”, Mendeleev Commun., 2001, Volume 11, Issue 6,Pages 222

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Stereospecific intramolecular cyclization of diethyl (R)-2-(N-benzylidene)-aminobutyl phosphite into (3R,5R)-2-ethoxy-2-oxo-3-phenyl-5-ethyl-1,4,2-oxazaphosphorinane in the presence of hydrogen chloride

M. N. Dimukhametov, E. Yu. Davydova, E. V. Bayandina, A. B. Dobrynin, I. A. Litvinov, V. A. Alfonsov

A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation

Abstract: Diethyl (R)-2-(N-benzylidene)aminobutyl phosphite, formed in reaction of (R)-(+)-2-(N-benzylidene)aminobutan-1-ol with diethyl chlorophosphite, undergoes stereospecific intramolecular cyclization to give P-epimeric (3R,5R)-2-ethoxy-2-oxo-3-phenyl-5-ethyl-1,4,2-oxazaphosphorinanes as final reaction products.

Language: English

DOI: 10.1070/MC2001v011n06ABEH001506