This article is cited in 5 papers

New approach to [a]-fused fluoroquinolones: the synthesis of 5-oxo-1,2,3,3a,4,5-hexahydropyrrolo[1,2-a]quinolines

E. Tsoi^a, V. N. Charushin^a, E. V. Nosova^a, G. N. Lipunova^a, A. V. Tkachev<sup>b

a</sup> Department of Organic Chemistry, Urals State Technical University, Ekaterinburg, Russian Federation
^b N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russian Federation

Abstract: The reaction of N-(ethoxycarbonyl)methyl substituted ethyl 6,7-difluoro-, 6,7,8-trifluoro- and 5,6,7,8-tetrafluoro-4-oxo-1,4-dihydroquinoline-3-carboxylates with methyl methacrylate results in the [3 + 2] adducts, hexahydropyrrolo[1,2-a]quinolones, which can be precursors of [a]-fused fluoroquinolones.

Language: English

DOI: 10.1070/MC2001v011n02ABEH001323

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