This article is cited in 80 papers

Nucleophilic aromatic substitution of hydrogen and related reactions

V. N. Charushin^ab, O. N. Chupakhin<sup>ab

a</sup> Department of Organic Chemistry, Urals State Technical University, Ekaterinburg, Russian Federation
^b I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Abstract: The classical concept of nucleophilic aromatic substitution (S_NAr^ipso) has been complemented with a new synthetic methodology (S^N_H), enabling one to build new carbon–carbon C(sp²)–C(sp³), C(sp²)–C(sp²) and C(sp²)–C(sp) or carbon–heteroatom C(sp²)–X (X is O, N, P, S, halogen) bonds through nucleophilic displacement of hydrogen in an aromatic ring.

Language: English

DOI: 10.1016/j.mencom.2007.09.001

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