Communications

Natural α-amino acid based synthesis of morpholin-2-ones, prospective monomers for new-generation polymeric lipofectants

E. D. Shaputkin^ab, I. E. Nifant'ev^ab, P. V. Ivchenko<sup>ab

a</sup> Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: N-Boc-protected morpholin-2-ones have been synthesized with a high to moderate yields from the natural L-amino acids (Ala, Val, Leu, Phe, Tyr). These compounds can find application in the development of biodegradable and biocompatible polymeric vehicles for DNA and RNA delivery.

Keywords: α-amino acids, CARTs, cyclization, gene delivery, lipofection, morpholin-2-ones, transfection, ring-opening polymerization.

Language: English

DOI: 10.1016/j.mencom.2024.01.009

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