This article is cited in 7 papers

Diastereoselective synthesis of 3-substituted acylamino-3,4-dihydro-1,2,4-triazinones

I. N. Egorov^a, B. König^b, V. L. Rusinov^a, O. N. Chupakhin<sup>ac

a</sup> Department of Organic Chemistry, Urals State Technical University, Ekaterinburg, Russian Federation
^b Institut für Organishce Chemie, Universität Regensburg, Regensburg, Germany
^c I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Abstract: 6-Phenyl-1,2,4-triazin-5(4H)-one 1 reacts with C-nucleophiles, such as indole, in the presence of N-acetylamino acids, to yield 2-acyl-3-indolyl-6-phenyl-3,4-dihydro-1,2,4-triazin-5(4H)-ones 2–6 with high diastereoselectivity.

Keywords: 1.2.4-triazines, diastereoselective synthesis, amino acids, indoles.

Language: English

DOI: 10.1016/j.mencom.2008.03.017

Bibliographic databases:

•