This article is cited in 8 papers

Communications

Doxorubicin delivery systems based on polypeptide nanoparticles for subcutaneous administration in cancer therapy

N. N. Sudareva^ab, I. I. Tarasenko^a, D. N. Suslov^c, O. M. Suvorova^a, K. A. Kolbe^a, G. Y. Yukina^b, M. L. Tyndyk^c, Yu. G. Zmitrichenko^c, E. G. Korzhikova-Vlakh<sup>ad

a</sup> Institute of Macromolecular Compounds, Russian Academy of Sciences, St. Petersburg, Russian Federation
^b I.P. Pavlov First St. Petersburg State Medical University, St. Petersburg, Russian Federation
^c N.N. Petrov National Medical Research Center of Oncology, St. Petersburg, Russian Federation
^d Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation

Abstract: Polypeptide-based doxorubicin delivery systems were prepared and their physicochemical and functional properties, such as size, encapsulation efficiency, stability, release of doxorubicin in various media and cytotoxicity, were characterized. An in vivo study revealed an effective reduction of tumor growth when these systems were administered subcutaneously.

Keywords: doxorubicin, synthetic polypeptides, nanoparticles, delivery systems, cancer treatment, subcutaneous administration.

Language: English

DOI: 10.1016/j.mencom.2024.01.006

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