This article is cited in 22 papers

Synthesis of 5-alkyl-2-amino-1,3,4-thiadiazoles and α,ω-bis(2-amino-1,3,4-thiadiazol-5-yl)alkanes in ionic liquids

M. A. Epishina^a, A. S. Kulikov^a, N. V. Ignat'ev^b, M. Schulte^b, N. N. Makhova<sup>a

a</sup> N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Ionic Liquid Research Laboratory, Merck KGaA, Darmstadt, Germany

Abstract: Reaction of thiosemicarbazide with carboxylic acids, including N-substituted amino acids, in ionic liquids with H₂SO₄ as a catalyst affords 5-R-2-amino-1,3,4-thiadiazoles. On using alkanedicarboxylic acids, α,ω-bis(2-amino-1,3,4,-thiadiazol-5-yl)alkanes were obtained.

Language: English

DOI: 10.1016/j.mencom.2011.11.013

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