This article is cited in 5 papers

Communications

Reductive α-alkylation of ketones with aldehydes at atmospheric pressure of carbon monoxide: the effect of fluoride activation in ruthenium catalysis

S. A. Runikhina^a, A. A. Tsygankov^a, O. I. Afanasyev^a, D. A. Chusov<sup>ab

a</sup> A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^b G.V. Plekhanov Russian University of Economics, Moscow, Russian Federation

Abstract: Fluoride additive to [(p-cymene)RuCl₂]₂, a readily available ruthenium catalyst, allows one to achieve milder conditions for the reductive alkylation of aldehydes with ketones using carbon monoxide as a reducing agent. The procedure is suitable for the broad substrate scope, and a probable explanation for the fluoride role was provided.

Keywords: carbon monoxide, fluoride activation, reductive addition, ruthenium, aldol reaction, aldehydes, ketones.

Language: English

DOI: 10.1016/j.mencom.2023.01.005

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