This article is cited in 1 paper

Communications

Selective Fmoc and Cbz protection of aromatic amino group in the presence of similar aliphatic function in liquid CO₂

D. A. Guk, R. O. Burlutsky, D. A. Lemenovskii, E. K. Beloglazkina

Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation

Abstract: The selective protection of an aromatic amino group in the presence of aliphatic amino group in diamines by the action of FmocCl or CbzCl using liquid CO₂ as the solvent has been proposed. The developed method is preparative, does not require complex purification of the product, and meets the principles of green chemistry.

Keywords: green chemistry, carbamic acids, protecting groups, diamines, liquid carbon dioxide.

Language: English

DOI: 10.1016/j.mencom.2023.01.004

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