This article is cited in 8 papers

Mannich Synthesis of Acetylenic Amino Alcohols in Aqueous Ionic Liquids

N. I. Simirskaya^a, N. V. Ignat'ev^b, M. Schulte^b, S. G. Zlotin<sup>a

a</sup> N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Ionic Liquid Research Laboratory, Merck KGaA, Darmstadt, Germany

Abstract: Terminal alkynols react with formaldehyde and secondary amines in aqueous ionic liquid [emim]HSO^–₄ in the presence of Cu(OAc) to afford the corresponding 1-(a-hydroxyalkyl)- or 1-(b-hydroxyalkyl)-2-(aminomethyl)acetylenes in better yields in comparison with the reaction in conventional organic solvents. The catalytic system can be easily recovered and recycled.

Language: English

DOI: 10.1016/j.mencom.2012.11.013

Bibliographic databases:

•