This article is cited in 5 papers

Ionic Liquids-assisted Synthesis of 3,4-Dihydroisoquinolines by the Bishler–Napieralski Reaction

M. A. Epishina^a, A. S. Kulikov^a, M. I. Struchkova^a, N. V. Ignat'ev^b, M. Schulte^b, N. N. Makhova<sup>a

a</sup> N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b Ionic Liquid Research Laboratory, Merck KGaA, Darmstadt, Germany

Abstract: The Bishler–Napieralski cyclodehydration of N-acyl-2-arylethylamines into the corresponding 3,4-dihydroisoquinolines with POCl3 as a dehydration reagent proceeds in ionic liquids under milder conditions and in higher yields.

Language: English

DOI: 10.1016/j.mencom.2012.09.014

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