This article is cited in 10 papers

Rational design and synthesis of novel Syk-kinase inhibitors

A. A. Zeifman^a, I. Yu. Titov^ab, I. Svitanko^b, T. V. Rakitina^cd, A. V. Lipkin^de, V. S. Stroylov^ab, O. V. Stroganov^ab, F. N. Novikov^a, G. G. Chilov<sup>ab

a</sup> MolTech Ltd, Moscow, Russian Federation
^b N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^c M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^d National Research Centre 'Kurchatov Institute', Moscow, Russian Federation
^e A.N. Bach Institute of Biochemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Molecular modeling and subsequent synthesis of novel Syk-kinase inhibitors, 7H-pyrrolo[2,3-d]pyrimidine and 1,3,5-triazine derivatives, have been carried out. The best of the obtained compounds demonstrated to inhibit Syk-kinase activity at IC₅₀ = 230±10 nM

Language: English

DOI: 10.1016/j.mencom.2012.03.006

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