This article is cited in 3 papers

Communications

Influence of Alzheimer's β-amyloid peptide on the lateral diffusion of lipids in raft-forming bilayers

A. V. Filippov^ab, O. N. Antzutkin<sup>bc

a</sup> Institute of Physics, Kazan Federal University, Kazan, Russian Federation
^b Chemistry of Interfaces, Luleå University of Technology, Luleå, Sweden
^c Department of Physics, Warwick University, Coventry, U.K.

Abstract: The effect of added Alzheimer's Aβ(1-40) peptide of the wild type on the lateral diffusion of lipids in macroscopically oriented bilayers of ‘raft’ compositions [a mixture of dioleoylphosphatidylcholine (DOPC), sphingomyelin (SM) and cholesterol (CHOL)] was studied by an NMR-diffusion technique. In homogeneous bilayers, diffusion coefficients decrease, while they change differently in liquid ordered and in liquid disordered phases at varied concentrations of CHOL; this was explained by the decreased maximum solubility of CHOL in phospholipids in the presence of Aβ(1-40) peptide.

Language: English

DOI: 10.1016/j.mencom.2013.11.003

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