This article is cited in 3 papers

KOH-Promoted Synthesis of Oxirane Functional Derivatives from Diethyl Bromomalonate and Aldehydes under Phase-Transfer Catalysis Conditions

G. V. Kryshtal', G. M. Zhdankina, S. G. Zlotin

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The Darzens condensation of diethyl bromomalonate with aromatic or isoprenoid aldehydes under heterogeneous conditions (KOH/MeCN) in the presence of Bu₄NPF₆ as a recoverable phase-transfer catalyst afforded the corresponding diethyl 3-R-oxirane-2,2-dicarboxylates in high yields.

Language: English

DOI: 10.1016/j.mencom.2013.01.008

Bibliographic databases:

•