This article is cited in 6 papers

Communications

Synthesis of the C⁶–C²¹ fragment of epothilone analogues

R. F. Valeev, R. F. Bikzhanov, M. S. Miftakhov

Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: (2S,4E,6Z,9S,10E)-9-[tert-Butyl(diphenyl)silyloxymethyl]-2,6,10-trimethyl-11-(2-methylthiazol-4-yl)undeca-4,6,10-trien-1-ol, a key precursor for epothilone analogues, was prepared by multi-step synthesis using the Julia–Kocienski olefination at the key step.

Language: English

DOI: 10.1016/j.mencom.2014.11.022

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