This article is cited in 19 papers

Focus Article

Dirhodium caprolactamate and tert-butyl hydro- peroxide – a universal system for selective oxidations

M. O. Ratnikov^a, M. P. Doyle<sup>b

a</sup> Department of Chemistry, The Scripps Research Institute, La Jolla, California, United States
^b Department of Chemistry and Biochemistry, University of Maryland, Maryland, USA

Abstract: Oxidations with tert-butyl hydroperoxide (TBHP) catalyzed by dirhodium caprolactamate [Rh₂(cap)₄] provide mild and selective protocols for the oxidative Mannich reaction, conversion of secondary amines to imines, dearomatization of 4-substituted phenols, and oxyfunctionalization of allylic, benzylic, and propargylic positions. The dirhodium catalyst in combination with TBHP is a convenient platform for mechanistic investigations, and their uses point to a variety of directions for the future evolution of the field.

Language: English

DOI: 10.1016/j.mencom.2014.06.001

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