This article is cited in 4 papers

Communications

A facile synthesis of regioisomeric 4-amino- and 6-amino-3-arylpyrazolo[3,4-b]pyridine-5-carbonitriles

P. A. Petrov, A. N. Kasatochkin, S. I. Selivanov

Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation

Abstract: Boiling of 3-aryl-1-R-1H-pyrazol-5-amines with ethoxymethylidenemalononitrile in butanol affords 6-amino-3-aryl-1-R-1H-pyrazolo-[3,4-b]pyridine-5-carbonitriles, whereas low temperature condensation of the same reactants followed by heating to 230°C in diphenyl ether gives the isomeric 4-amino derivatives.

Language: English

DOI: 10.1016/j.mencom.2015.09.023

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