This article is cited in 13 papers

Communications

Polycarboxylic fullerene derivatives as protein tyrosine phosphatase inhibitors

O. L. Kobzar^a, V. V. Trush^a, V. Yu. Tanchuk^a, I. I. Voronov^b, A. S. Peregudov^c, P. A. Troshin^b, A. I. Vovk<sup>a

a</sup> Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, Kiev, Ukraine
^b Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The study of the inhibition of human protein tyrosine phosphatases by water-soluble [60]fullerene derivatives bearing five organic addends loaded with carboxylic groups demonstrated that a fullerene core is responsible for interactions with the enzymes while organic addends play a minor role modifying the selectivity of the inhibition.

Language: English

DOI: 10.1016/j.mencom.2015.05.013

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