This article is cited in 20 papers

Communications

Asymmetric aldol reactions in ketone/ketone systems catalyzed by ionic liquid-supported C₂-symmetrical organocatalyst

S. V. Kochetkov, A. S. Kucherenko, S. G. Zlotin

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Ionic liquid-supported (1S,2S)- and (1R,2R)-1,2-bis[(S)-prolinamido]-1,2-diphenylethanes act as organocatalysts in asymmetric aldol reactions of acetone with α-keto esters or trifluoroacetophenone providing high yields and from moderate to high enantioselectivity. Recycling of the catalyst with a gradual decrease in conversion and ee values is possible.

Language: English

DOI: 10.1016/j.mencom.2015.05.002

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