This article is cited in 30 papers

Communications

New insight into the antiaggregant activity of furoxans

N. E. Ustyuzhanina, L. L. Fershtat, M. L. Gening, N. E. Nifantiev, N. N. Makhova

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The measurement of the antiaggregant properties of 3-cyano-4-phenylfuroxan and 3-nitro-4-phenylfuroxan has demonstrated that these compounds effectively inhibit platelet agglutination induced by adenosine diphosphate and adrenaline but not ristocetin. When collagen was used as an inducer, only a slight delay of aggregate formation was observed. Therefore, these furoxan derivatives could be considered as a basis for the development of next generation agents with improved antiaggregant activity.

Language: English

DOI: 10.1016/j.mencom.2016.11.018

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