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Focus Article

Self-assembly strategy for the design of soft nanocontainers with controlled properties

L. Ya. Zakharova^ab, R. R. Kashapov^a, T. N. Pashirova^a, A. B. Mirgorodskaya^a, O. G. Sinyashin<sup>ab

a</sup> Kazan National Research Technological University, Kazan, Russian Federation
^b A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation

Abstract: Organized systems based on amphiphiles are discussed from the viewpoint of their application as solubilizing agents and drug and gene delivery systems with structure–activity relationships and stimuli responsibility emphasized. Special attention is paid to cationic surfactants, including gemini and naturally originated compounds. Practically important lipid formulations, i.e., liposomes and solid lipid nanoparticles, are discussed in terms of their stability, loading capacity, surface modification and therapeutic efficacy. The stimuli responsibility of formulations is analyzed and exemplified by smart supramolecular systems based on a calixarene platform.

Language: English

DOI: 10.1016/j.mencom.2016.11.001

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