This article is cited in 16 papers

Focus Article

The next generation of positron emission tomography radiopharmaceuticals labeled with non-conventional radionuclides

R. N. Krasikova^ab, R. A. Aliev^cd, S. N. Kalmykov<sup>cd

a</sup> N.P. Bekhtereva Institute of the Human Brain, Russian Academy of Sciences, St. Petersburg, Russian Federation
^b Institute of Chemistry, St. Petersburg State University, St. Petersburg, Russian Federation
^c Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^d National Research Centre 'Kurchatov Institute', Moscow, Russian Federation

Abstract: The nuclear and chemical properties of ‘non-traditional’ positron emission tomography (PET) radionuclides, i.e. ⁴⁴Sc, ^61,64Cu, ⁶⁸Ga, ⁸⁶Y, ⁸⁹Zr, as well as their production routes are discussed. The bio-conjugation of these radionuclides with various vectors for target delivery to tumor cells using bifunctional chelating agents is reviewed. The applications of various radiopharmaceuticals with ‘non-traditional’ PET radionuclides for molecular visualization of various tumors are summarized.

Language: English

DOI: 10.1016/j.mencom.2016.03.001

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