This article is cited in 8 papers

Communications

Chemoenzymatic arabinosylation of 2-aminopurines bearing the chiral fragment of 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines

B. Z. Eletskaya^a, I. D. Konstantinova^a, A. S. Paramonov^a, R. S. Esipov^a, D. A. Gruzdev^b, A. Yu. Vigorov^b, G. L. Levit^b, A. I. Miroshnikov^a, V. P. Krasnov^b, V. N. Charushin<sup>b

a</sup> M.M. Shemyakin–Yu.A. Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b I.Ya. Postovsky Institute of Organic Synthesis, Ural Branch of the Russian Academy of Sciences, Ekaterinburg, Russian Federation

Abstract: Chemoenzymatic transglycosylation of 2-aminopurine conjugates with enantiomerically pure 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines under the action of recombinant E. coli purine nucleoside phosphorylase afforded the corresponding arabinofuranosides, yields of the target compounds being dependent on both the structure and configuration of the fragment of heterocyclic amine attached at C-6 position of purine moiety.

Language: English

DOI: 10.1016/j.mencom.2016.01.003

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