This article is cited in 26 papers

Communications

Solvent-free Buchwald–Hartwig amination with low palladium loadings

G. A. Chesnokov^a, P. S. Gribanov^b, M. A. Topchiy^b, L. I. Minaeva^c, A. F. Asachenko^bc, M. S. Nechaev^ab, E. V. Bermesheva^ad, M. V. Bermeshev<sup>b

a</sup> Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b A.V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow, Russian Federation
^c Peoples Friendship University of Russia (RUDN University), Moscow, Russian Federation
^d I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation

Abstract: A highly efficient ‘green’ solvent-free monoarylation of primary anilines with aryl bromides mediated by the expanded-ring N-heterocyclic carbene palladium complex (THP-Dipp)Pd(cinn)Cl [THP-Dipp is 1,3-bis(2,6-diisopropylphenyl)-3,4,5,6-tetrahydropyrimidin-2-ylidene; cinn is cinnamyl] can be performed at low catalyst loadings (0.1 mol%) to provide excellent yields and remarkable selectivities for various substrates.

Language: English

DOI: 10.1016/j.mencom.2017.11.027

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