This article is cited in 20 papers

Communications

New hybrid furoxan structures with antiaggregant activity

A. A. Larin, L. L. Fershtat, N. E. Ustyuzhanina, M. L. Gening, N. E. Nifantiev, N. N. Makhova

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A series of functionalized furoxans was synthesized, and their effect on the platelet aggregation was estimated using a set of inducers. New hybrid structures comprising the furoxan ring and glycolic or acetylsalicylic acid motifs effectively inhibit aggregate formation induced by adenosine diphosphate and adrenaline. Studies of their NO-donor ability showed that their antiplatelet effects were mainly independent of the NO action.

Language: English

DOI: 10.1016/j.mencom.2018.11.010

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