This article is cited in 31 papers

Communications

Antiaggregant activity of water-soluble furoxans

N. E. Ustyuzhanina, L. L. Fershtat, M. L. Gening, N. E. Nifantiev, N. N. Makhova

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The effect of the water-soluble furoxan derivatives on platelet aggregation has been estimated using a series of inducers. The most active compound, 3-carbamoyl-4-(hydroxymethyl)furoxan (CAS-1609), effectively inhibits aggregate formation induced by adenosine diphosphate and adrenaline. This result is a good basis for the search of new structures with antiaggregant activity among furoxancarboxylic acid amides.

Language: English

DOI: 10.1016/j.mencom.2018.01.016

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