This article is cited in 4 papers

Communications

Nanosized systems of aluminum phthalocyanine and amphiphilic copolymers of N-vinylpyrrolidone with mono- and dimethacrylates for photodynamic therapy and fluorescence diagnostics

S. V. Kurmaz, I. V. Ulyanov, N. S. Emelyanova, V. A. Kurmaz, A. V. Kozlov, L. R. Sizov, A. Yu. Rybkin

Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

Abstract: Water-soluble nanosized systems of aluminum phthalo- cyanine, which is a promising photosensitizer for photodynamic therapy and fluorescence diagnostics, were obtained by encapsulating it in biocompatible copolymers of N-vinylpyrrolidone with mono- and dimethacrylates. The physicochemical (water solubility, stability and size of nanoparticles) and photophysical (absorption and fluorescence) properties of the resulting nanoparticles in aqueous solution were determined. Quantum chemical modeling revealed the formation of coordination bonds between the Al atom of the dye and the oxygen atoms of all monomer units.

Keywords: N-vinylpyrrolidone, dimethacrylates, terpolymer, aluminum phthalocyanine, encapsulation, fluorescence, quantum chemical modeling.

Language: English

DOI: 10.1016/j.mencom.2024.06.007

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