This article is cited in 17 papers

Communications

Tricyclic derivatives of bispidine as AMPA receptor allosteric modulators

M. I. Lavrov^ab, P. N. Veremeeva^a, D. S. Karlov^ac, V. L. Zamoyski^b, V. V. Grigoriev^ab, V. A. Palyulin<sup>ab

a</sup> Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Institute of Physiologically Active Compounds, Federal Research Center of Problems of Chemical Physics and Medicinal Chemistry, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation
^c Skolkovo Institute of Science and Technology, Moscow, Russian Federation

Abstract: Four new tricyclic derivatives of 3,7-diazabicyclo[3.3.1]-nonane (bispidine) have been synthesized. In vitro patch clamp investigation has revealed for one of them the positive modulation of the kainate-induced AMPA receptor currents in a nanomolar concentration range, and for two other compounds the corresponding negative modulation has been demonstrated.

Language: English

DOI: 10.1016/j.mencom.2019.11.004

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