This article is cited in 9 papers

Communications

Synthesis of new pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans

M. A. Epishina^a, A. S. Kulikov^a, L. L. Fershtat^a, I. V. Ananyev^bc, N. N. Makhova<sup>a

a</sup> N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
^b A.N. Nesmeyanov Institute of Organoelement Compounds of Russian Academy of Sciences, Moscow, Russian Federation
^c G.V. Plekhanov Russian University of Economics, Moscow, Russian Federation

Abstract: The effective synthesis of pharmacologically oriented heterocyclic ensembles, [2-(1H-pyrazol-1-yl)thiazol-4-yl]furoxans, comprising furoxan moiety as NO-donor and pharmacophoric pyrazolylthiazole fragment is based on the condensation of (2-hydrazinylthiazol-4-yl)furoxan hydrobromides with linear 1,3-diketones. The reaction proceeds through hydroxypyrazoline intermediate.

Language: English

DOI: 10.1016/j.mencom.2019.05.015

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