This article is cited in 1 paper

Communications

Synthesis and biological evaluation of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors

G. B. Lapa^a, A. A. Lapa<sup>b

a</sup> N.I. Pirogov Russian National Research Medical University, Moscow, Russian Federation
^b Sandoz Pharmaceutical, Moscow, Russian Federation

Abstract: The library of new N-substituted 4-(arylmethoxy)piperidines as dopamine transporter inhibitors was designed and synthesized. H-Bond donors in piperidine ring were found to be important for reduced locomotor activity in mice. 4-[Bis(4-fluorophenyl)methoxy]piperidine has IC₅₀ 17.0±1.0nm for dopamine transporter and locomotor activity, which is lower than that for cocaine.

Language: English

DOI: 10.1016/j.mencom.2019.03.030

Bibliographic databases:

•