This article is cited in 1 paper

Communications

Polycomplexes to modulate bactericidal activity of cetylpyridinium bromide

O. A. Novoskoltseva^a, D. G. Sinelnikova^a, N. G. Loiko^b, Yu. A. Nikolaev^b, A. A. Yaroslavov<sup>a

a</sup> Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow, Russian Federation
^b Federal Research Centre 'Fundamentals of Biotechnology' of the Russian Academy of Sciences, Moscow, Russian Federation

Abstract: Cetylpyridinium bromide, a quaternary ammonium surfactant, was electrostatically complexed with an excess of anionic polymers such as biodegradable sodium alginate or non-biodegradable sodium polyacrylate. The binding of surfactant with alginate delivered polymer–surfactant complexes capable of killing both more surfactant-sensitive Escherichia coli and less surfactant-sensitive Pseudomonas aeruginosa bacteria, while the binding with acrylate gave complexes active only against Escherichia coli. The results obtained show a way for adjustment of the antimicrobial formulation to a specific pathogen to be destroyed.

Keywords: polymer–surfactant complexes, quaternary ammonium compounds, pyridinium salts, biodegradable polymers, bactericides, gram-negative bacteria, minimum inhibitory concentration.

Language: English

DOI: 10.1016/j.mencom.2024.04.018

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