This article is cited in 3 papers

Communications

A convenient synthesis of new (1,2,4-triazolylamino)pyrimidines from cyanamide precursor

M. A. Prezent, S. V. Baranin, Yu. N. Bubnov

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: The Ni(acac)₂-catalyzed 1,2,4-triazole formation from cyanamides and carbohydrazides was extended onto N-(4,6-dimethylpyrimidin-2-yl)cyanamide and glycine hydrazides. The obtained N-(5-aminomethyl-4H-1,2,4-triazol-3-yl)-4,6-dimethylpyrimidin-2-amines may be attractive for the estimation of their biological activity.

Keywords: Boc-deprotection, amino acids, hydrazides, pyrimidines, cyanamides, piperazines, 1,2,4-triazoles, heterocyclization.

Language: English

DOI: 10.1016/j.mencom.2020.07.032

Bibliographic databases:

•