This article is cited in 12 papers

Focus Article

Natural chlorins as a promising platform for creating targeted theranostics in oncology

M. A. Grin, N. V. Suvorov, A. F. Mironov

M.V. Lomonosov Institute of Fine Chemical Technologies, MIREA - Russian Technological University, Moscow, Russian Federation

Abstract: This review deals with the progress in the chemistry of natural chlorins and the prospects of using their derivatives as theranostics. Particular attention is paid to the creation of targeted photosensitizers by addition of vector molecules to chlorins and bacteriochlorins, or by immobilization onto nanoparticles of various nature. The results of biological tests that establish relationship between the structure, antitumor activity, and diagnostic potential of the resulting photosensitizers are presented.

Keywords: chlorins, bacteriochlorins, photodynamic therapy, targeted photosensitizers, nanoparticles, fluorescence diagnostics.

Language: English

DOI: 10.1016/j.mencom.2020.07.003

Bibliographic databases:

•