This article is cited in 8 papers

Communications

Synthesis of new alkynyl containing 9-azabicyclo[4.2.1]nonatrienes from diynes and azepines

G. N. Kadikova, V. A. D'yakonov, R. N. Nasretdinov, L. U. Dzhemileva, U. M. Dzhemilev

Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: New 7-alkynyl-9-azabicyclo[4.2.1]nona-2,4,7-triene-9carboxylates were obtained upon the Co(acac)₂(dppe)/Zn/ZnI₂catalyzed [6p+2p]-cycloaddition of 1,3-diynes to ethyl/phenyl azepine-1-carboxylates. The structures of the obtained azacyclic compounds were established by 1D and 2D NMR spectroscopy. The compounds prepared were tested for antitumor activities in vitro against Jurkat, K562, U937 and HL60 cancer cell lines.

Keywords: cycloaddition, catalytic systems, azepine-1-carboxylates, 1,3-diynes, 9-azabicyclo[4.2.1]nona-2,4,7-trienes, cobalt complexes, antitumor activity.

Language: English

DOI: 10.1016/j.mencom.2020.05.019

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