This article is cited in 3 papers

Communications

Synthesis and antitumor activity of methanofullerenes equipped with norbornadiene and quadricyclane moieties

U. M. Dzhemilev, A. R. Akhmetov, V. A. D'yakonov, L. U. Dzhemileva, M. M. Yunusbaeva, A. R. Tuktarov

Institute of Petrochemistry and Catalysis, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: Hybrids composed of 3-pentylnorbornadiene-2-carboxylic acid or its quadricyclane isomer molecules linked to methano-C₆₀ fullerene via triethylene glycol spacer were synthesized by the Bingel–Hirsch reaction. The quadricyclane derivative possesses markedly higher apoptosis-inducing activity against the Jurkat tumor cells than the norbornadiene one.

Keywords: C₆₀ fullerene, norbornadiene, quadricyclane, methanofullerenes, cytotoxic activity.

Language: English

DOI: 10.1016/j.mencom.2020.03.006

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