This article is cited in 2 papers

Communications

Anticancer activity of new benzofuroxan–imidazolone hybrids

E. A. Chugunova^a, A. V. Smolobochkin^a, A. S. Gazizov^a, A. R. Burilov^a, A. D. Voloshina^a, A. P. Lyubina^a, S. K. Amerhanova^a, T. A. Melnikova^b, A. I. Tulesinova^b, N. I. Akylbekov^c, N. A. Akhatayev^c, V. V. Syakaev<sup>a

a</sup> A.E. Arbuzov Institute of Organic and Physical Chemistry, FRC Kazan Scientific Center of the Russian Academy of Sciences, Kazan, Russian Federation
^b Kazan National Research Technological University, Kazan, Russian Federation
^c Korkyt Ata Kyzylorda University, Kyzylorda, Republic of Kazakhstan

Abstract: Novel hybrid compounds containing both benzofuroxan and 1H-imidazol-2(3H)-one moieties were synthesized by an S_NAr reaction between 7-chloro-4,6-dinitrobenzofuroxan and imidazol-2-ones, with the only C⁴ regioisomer having been formed. Cytotoxic effects of parent and obtained compounds were estimated on human cancer and normal cells, while two of imidazolones showed higher cytotoxicity in relation to the M-HeLa cancer line compared to the hybrid products. In relation to the normal liver cell line Chang, the tested compounds were found to be non-toxic and can be promising for further development of anticancer agents.

Keywords: benzofuroxans, imidazol-2-ones, hybrid compounds, SNAr reaction, regioselective synthesis, antitumor activity.

Language: English

DOI: 10.1016/j.mencom.2021.11.032

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