This article is cited in 3 papers

Communications

An efficient access to tetrahydropyrrolo[2,1-a]isoquinoline derivatives based on phosphoranylidene succinimide

G. F. Sakhautdinova, I. M. Sakhautdinov

Ufa Institute of Chemistry, Ufa Federal Research Centre of the Russian Academy of Sciences, Ufa, Russian Federation

Abstract: A simple and convenient synthesis of new isoquinolinone derivatives based on N-(homoveratryl)succinimide phosphorus ylide and natural aldehydes is suggested. The final formation of the tetrahydropyrrolo[2,1-a]isoquinoline framework occurs via the Pictet–Spengler cyclization.

Keywords: isoquinoline, phosphorus ylide, N-(homoveratryl)maleimide, alkaloids, homoveratrylamine, tetrahydropyrrolo[2,1-a]iso-quinoline, Pictet–Spengler reaction.

Language: English

DOI: 10.1016/j.mencom.2024.02.036

Bibliographic databases:

•