This article is cited in 5 papers

Communications

One-pot synthesis of α-trifluoromethylstyrenes from aryl ketones and the Ruppert–Prakash reagent

V. V. Levin, A. D. Dilman

N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation

Abstract: A new synthesis of α-trifluoromethylstyrenes from aromatic ketones and (trifluoromethyl) trimethylsilane is described. The reaction involves nucleophilic trifluoromethylation and elimination of trimethylsilanol, which are performed within one reaction flask.

Keywords: organofluorine compounds, trifluoromethylation, silicon reagents, ketones, alkenes.

Language: English

DOI: 10.1016/j.mencom.2021.09.030

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