Comments

Commentary on the Work of Jimak S.S. et al. "Mathematical Modeling of Open States in Double Stranded DNA Molecule Depending on $^2$H/$^1$H Ratio"

A. S. Shigaev

Institute of Mathematical Biology RAS, M.V. Keldysh Institute of Applied Mathematics of RAS, Pushchino, Russia

Abstract: The article is analyzed Jimak S.S. et al. "Mathematical modeling of open state accounting as a function of $^2$H/$^1$H ratio in a double-stranded DNA molecule", appeared in “Mathematical Biology and Bioinformatics”. The values of H-bond energies used in the simulation as a parameter are estimated. A new mechanism for the effect of DNA deuteration on biological function of DNA described by authors is proposed.

Key words: open state of DNA, DNA deuteration, angular mechanical model.

Received 22.12.2019, Published 16.01.2020

DOI: 10.17537/2020.15.1