This article is cited in 1 paper

Bioinformatics

Identification of Gene Markers for Aggressive Forms of Low-Grade Glioma Using TCGA Expression Data

N. V. Ivanisenko^ab, N. V. Gubanova^ab, N. A. Kolchanov^b, V. A. Ivanisenko<sup>b

a</sup> Novosibirsk State University, Novosibirsk, Russia
^b Institute of Cytology and Genetics SB RAS, Novosibirsk, Russia

Abstract: Low-grade glioma is a group of tumors of central nervous system. Unlike other malignant subtypes such as glioblastoma multiforme, low-grade gliomas have a lower mortality. However, after initial treatment in about 40% of low-grade gliomas new tumor events are observed. In this study identification of new genes responsible for the aggressive phenotype of tumors was carried out using RNA-seq data from the The Cancer Genome Atlas (TCGA) database. It was found that 85 genes with affected expression levels were associated with new tumors after initial treatment of low-grade glioma.

Key words: low-grade glioma, RNA-seq, new tumor event, TCGA.

UDC: 577.21:577.29:004.42

Received 27.11.2014, Published 18.12.2014