I. A. Nyapshaev, A. V. Ankudinov, A. V. Stovpyaga, E. Yu. Trofimova, M. Yu. Eropkin, “Diagnostics of living cells under an atomic force microscope using a submicron spherical probe with a calibrated radius of curvature”, Zhurnal Tekhnicheskoi Fiziki, 2012, Volume 82, Issue 10,Pages <nobr>109

This article is cited in 9 papers

Experimental Instruments and Methods

Diagnostics of living cells under an atomic force microscope using a submicron spherical probe with a calibrated radius of curvature

I. A. Nyapshaev^a, A. V. Ankudinov^ab, A. V. Stovpyaga^b, E. Yu. Trofimova^a, M. Yu. Eropkin^c

^a Ioffe Institute, St. Petersburg
^b St. Petersburg National Research University of Information Technologies, Mechanics and Optics
^c Grippe Research Institute of the Russian Academy of Medical Sciences

Abstract: The relief and mechanical elasticity of living cells from lines A549 and L41 are studied. To minimize the destructive effect of the atomic force microscope on the cell and improve the measuring accuracy of the elasticity module, special probes with a single colloid amorphous SiO$_2$ nanogranule at their tips are employed. A procedure for preparing such probes is demonstrated.

Received: 12.12.2011