K. G. Kulikov, T. V. Koshlan, “Simulation of the type of coralin alkaloid-DNA binding”, Zhurnal Tekhnicheskoi Fiziki, 2015, Volume 85, Issue 5,Pages <nobr>5

This article is cited in 4 papers

Theoretical and Mathematical Physics

Simulation of the type of coralin alkaloid-DNA binding

K. G. Kulikov^a, T. V. Koshlan^b

^a Peter the Great St. Petersburg Polytechnic University
^b Saint Petersburg State University, 199034 Санкт-Петербург, Россия

Abstract: Interaction between a synthesized coralin protoberberine alkaloid and the DNA double helix of the calf’s thymus in a salt solution is studied by optical absorption spectroscopy and spectropolarimetry. The dependence of the spectral characteristics of the alkaloid on a ratio between the DNA base pair concentration and the alkaloid molecule concentration is considered. The parameters of bonds between the coralin alkaloid and the DNA double helix are determined using modified McGhee-von Hippel equations.

Received: 01.10.2014