Physics for sciences of life

Broadband dielectric spectroscopy of human albumin solution at physiological temperatures

Zh. A. Salnikova, A. A. Kononov, A. P. Smirnov, R. A. Castro

Herzen State Pedagogical University of Russia, Institute of Physics, St. Petersburg

Abstract: The paper defines and analyzes the parameters of relaxation processes in human albumin solution by dielectric spectroscopy through the analysis of the behavior of a complex electrical module in a wide frequency range (1 Hz–2 GHz) and in the range of physiological temperatures 33–42$^\circ$C. Three relaxation processes were discovered and, based on their approximation by the Havriliak–Negami equation for a complex electrical module, their relaxation parameters $\alpha$, $\beta$, $\tau_0$ were determined, the time distribution functions of the relaxators $G(\tau)$ were constructed, and their activation energies $E_a$ were calculated. Assumptions are made regarding the identification of possible kinetic units responsible for these processes.

Keywords: complex electrical module, relaxation parameters, Havriliak–Negami equation, time distribution function of relaxers.

DOI: 10.61011/JTF.2025.06.60474.427-24

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